Properties of Viagra Soft

Pharmacokinetic properties include the absorption rate of the drug, its distribution, metabolic processes, and excretion.

 

Absorption

Viagra Soft is normally absorbed in a short time. The concentration of the drug in the blood after ingestion reaches its maximum effect in 20-120 minutes. The average value is noted in 60 minutes.

 

Full bioavailability of Viagra Soft is approximately 41%. The availability interval has the following percentages: from 25% to 63%. After using Viagra Soft pills for Canadians from 25 mg to 100 mg, the pharmacokinetics are linear. After using the drug in combination with high-calorie food, the rate of absorption of the active substance is reduced to a negligible extent.

 

Distribution

The volume fraction distribution of sildenafil, the basic component of the drug, is approximately 105 liters in a static arrangement, which means its dispersal in the muscles of the genital organ. The main substance of sildenafil, circulating M-desmethyl metabolite, binds to blood proteins by 96%.

 

The total concentration of the Viagra Soft for Canadians does not depend on its connection with proteins. In healthy subjects who were tested, the following concentration of the drug was determined in the seed in 1.5 hours after the use of the drug: 0.0002%. With a single use of 100 mg, 188 ng was found.

 

Metabolism

The sildenafil substance is concentrated solely under the action of CYP3A4, as the main pathway and CYP2C9, as an additional, in the microsomal isoenzyme of the liver. Based on the selectivity of the effect on phosphodiesterase, the metabolite is commensurable with the substance sildenafil .Its intensification by type 5 PDE compiles approximately 50% than the intensity of the drug itself.

 

The concentration of the metabolite in the blood is approximately 40% than the concentration of sildenafil in it .M- desmethyl metabolite substance undergoes further metabolism. The complete half-life of the substance is about 4 hours.

 

Excretion

The excretion period of sildenafil from the human blood is 41 liters per hour. The maximum half-life is up to 5 hours. Sometime later after ingestion or through intravenous administration, the substance is excreted to a greater extent, forming metabolites (almost 80% of the dose used) with a caloric mass and to the least extent (less than 20%) in the urine.